Glutathione Depletion and Carbon Ion Radiation Potentiate Clustered DNA Lesions, Cell Death and Prevent Chromosomal Changes in Cancer Cells Progeny

Poor local control and tumor escape are of major concern in head-and-neck cancers treated by conventional radiotherapy or hadrontherapy. Reduced glutathione (GSH) is suspected of playing an important role in mechanisms leading to radioresistance, and its depletion should enable oxidative stress insu...

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Detalles Bibliográficos
Autores principales: Hanot, Maïté, Boivin, Anthony, Malésys, Céline, Beuve, Michaël, Colliaux, Anthony, Foray, Nicolas, Douki, Thierry, Ardail, Dominique, Rodriguez-Lafrasse, Claire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502420/
https://www.ncbi.nlm.nih.gov/pubmed/23185232
http://dx.doi.org/10.1371/journal.pone.0044367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502420/
https://www.ncbi.nlm.nih.gov/pubmed/23185232
http://dx.doi.org/10.1371/journal.pone.0044367

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