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Generation of anti-Notch antibodies and their application in blocking Notch signalling in neural stem cells

Notch signalling occurs via direct cell–cell interactions and plays an important role in linking the fates of neighbouring cells. There are four different mammalian Notch receptors that can be activated by five cell surface ligands. The ability to inhibit specific Notch receptors would help identify...

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Detalles Bibliográficos
Autores principales: Falk, Ronny, Falk, Anna, Dyson, Michael R., Melidoni, Anna N., Parthiban, Kothai, Young, Joyce L., Roake, Wendy, McCafferty, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502869/
https://www.ncbi.nlm.nih.gov/pubmed/22842086
http://dx.doi.org/10.1016/j.ymeth.2012.07.008