Comparative analysis of SV40 17kT and LT function in vivo demonstrates that LT's C-terminus re-programs hepatic gene expression and is necessary for tumorigenesis in the liver

Transformation by Simian Virus 40 (SV40) large T antigen (LT) is mediated in large part by its interaction with a variety of cellular proteins at distinct binding domains within LT. While the interaction of LT's N-terminus with the tumor suppressor Rb is absolutely required for LT-dependent tra...

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Detalles Bibliográficos
Autores principales: Comerford, S A, Schultz, N, Hinnant, E A, Klapproth, S, Hammer, R E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503294/
https://www.ncbi.nlm.nih.gov/pubmed/23552841
http://dx.doi.org/10.1038/oncsis.2012.27

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503294/
https://www.ncbi.nlm.nih.gov/pubmed/23552841
http://dx.doi.org/10.1038/oncsis.2012.27

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