Generation of a selectively cytotoxic fusion protein against p53 mutated cancers

BACKGROUND: A significant number of cancers are caused by defects in p21 causing functional defects in p21 or p53 tumour-suppressor proteins. This has led to many therapeutic approaches including restoration by gene therapy with wild-type p53 or p21 using viral or liposomal vectors, which have toxic...

Descripción completa

Detalles Bibliográficos
Autores principales: Kousparou, Christina A, Yiacoumi, Efthymia, Deonarain, Mahendra P, Epenetos, Agamemnon A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503689/
https://www.ncbi.nlm.nih.gov/pubmed/22862878
http://dx.doi.org/10.1186/1471-2407-12-338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503689/
https://www.ncbi.nlm.nih.gov/pubmed/22862878
http://dx.doi.org/10.1186/1471-2407-12-338

Ejemplares similares