Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain

Circular permutation is a common molecular mechanism for evolution of proteins. However, such re-arrangement of secondary structure connectivity may interfere with the folding mechanism causing accumulation of folding intermediates, which in turn can lead to misfolding. We solved the crystal structu...

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Detalles Bibliográficos
Autores principales: Hultqvist, Greta, Punekar, Avinash S., Morrone, Angela, Chi, Celestine N., Engström, Åke, Selmer, Maria, Gianni, Stefano, Jemth, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503759/
https://www.ncbi.nlm.nih.gov/pubmed/23185531
http://dx.doi.org/10.1371/journal.pone.0050055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503759/
https://www.ncbi.nlm.nih.gov/pubmed/23185531
http://dx.doi.org/10.1371/journal.pone.0050055

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