Cargando…

Importance of a Conserved Sequence Motif in Transmembrane Segment S3 for the Gating of Human TRPM8 and TRPM2

For mammalian TRPM8, the amino acid residues asparagine-799 and aspartate-802 are essential for the stimulation of the channel by the synthetic agonist icilin. Both residues belong to the short sequence motif N-x-x-D within the transmembrane segment S3 highly conserved in the entire superfamily of v...

Descripción completa

Detalles Bibliográficos
Autores principales: Winking, Mathis, Hoffmann, Daniel C., Kühn, Cornelia, Hilgers, Ralf-Dieter, Lückhoff, Andreas, Kühn, Frank J. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503820/
https://www.ncbi.nlm.nih.gov/pubmed/23185472
http://dx.doi.org/10.1371/journal.pone.0049877