Genetic Deficiency in Neprilysin or Its Pharmacological Inhibition Initiate Excessive Stress-Induced Alcohol Consumption in Mice

Both acquired and inherited genetic factors contribute to excessive alcohol consumption and the corresponding development of addiction. Here we show that the genetic deficiency in neprilysin [NEP] did not change the kinetics of alcohol degradation but led to an increase in alcohol intake in mice in...

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Detalles Bibliográficos
Autores principales: Maul, Björn, Becker, Matthias, Gembardt, Florian, Becker, Axel, Schultheiss, Heinz-Peter, Siems, Wolf-Eberhard, Walther, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503995/
https://www.ncbi.nlm.nih.gov/pubmed/23185571
http://dx.doi.org/10.1371/journal.pone.0050187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503995/
https://www.ncbi.nlm.nih.gov/pubmed/23185571
http://dx.doi.org/10.1371/journal.pone.0050187

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