High CCR5 Density on Central Memory CD4(+) T Cells in Acute HIV-1 Infection Is Mostly Associated with Rapid Disease Progression

CD4+ central memory T cells play a critical role in the pathogenesis of simian immunodeficiency virus disease, and the CCR5 density on the surface of CD4 T cells is an important factor in human immunodeficiency virus (HIV)-1 disease progression. We hypothesized that quantifying central memory cells...

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Autores principales: Yang, Xue, Jiao, Yan-mei, Wang, Rui, Ji, Yun-xia, Zhang, Hong-wei, Zhang, Yong-hong, Chen, De-xi, Zhang, Tong, Wu, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504013/
https://www.ncbi.nlm.nih.gov/pubmed/23185351
http://dx.doi.org/10.1371/journal.pone.0049526
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author Yang, Xue
Jiao, Yan-mei
Wang, Rui
Ji, Yun-xia
Zhang, Hong-wei
Zhang, Yong-hong
Chen, De-xi
Zhang, Tong
Wu, Hao
author_facet Yang, Xue
Jiao, Yan-mei
Wang, Rui
Ji, Yun-xia
Zhang, Hong-wei
Zhang, Yong-hong
Chen, De-xi
Zhang, Tong
Wu, Hao
author_sort Yang, Xue
collection PubMed
description CD4+ central memory T cells play a critical role in the pathogenesis of simian immunodeficiency virus disease, and the CCR5 density on the surface of CD4 T cells is an important factor in human immunodeficiency virus (HIV)-1 disease progression. We hypothesized that quantifying central memory cells and CCR5 expression in the early stages of HIV-infection could provide useful prognostic information. We enrolled two different groups of acute HIV-infected subjects. One group progressed to CD4 T cell numbers below 250 cells/µl within 2 years (CD4 Low group), while the other group maintained CD4 cell counts above 450 cells/µl over 2 years (CD4 High group). We compared the CCR5 levels and percentage of CD4 subsets between the two groups during the 1st year of HIV infection. We found no differences between the two groups regarding the percentage of naïve, central memory and effector memory subsets of CD4 cells during the 1st year of HIV-1 infection. CCR5 levels on CD4+ CM subset was higher in the CD4 Low group compared with the CD4 High group during the 1st year of HIV-1 infection. High CCR5 levels on CD4 central memory cells in acute HIV infection are mostly associated with rapid disease progression. Our data suggest that low CCR5 expression on CD4 central memory cells protects CD4 cells from direct virus infection and favors the preservation of CD4(+) T cell homeostasis.
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spelling pubmed-35040132012-11-26 High CCR5 Density on Central Memory CD4(+) T Cells in Acute HIV-1 Infection Is Mostly Associated with Rapid Disease Progression Yang, Xue Jiao, Yan-mei Wang, Rui Ji, Yun-xia Zhang, Hong-wei Zhang, Yong-hong Chen, De-xi Zhang, Tong Wu, Hao PLoS One Research Article CD4+ central memory T cells play a critical role in the pathogenesis of simian immunodeficiency virus disease, and the CCR5 density on the surface of CD4 T cells is an important factor in human immunodeficiency virus (HIV)-1 disease progression. We hypothesized that quantifying central memory cells and CCR5 expression in the early stages of HIV-infection could provide useful prognostic information. We enrolled two different groups of acute HIV-infected subjects. One group progressed to CD4 T cell numbers below 250 cells/µl within 2 years (CD4 Low group), while the other group maintained CD4 cell counts above 450 cells/µl over 2 years (CD4 High group). We compared the CCR5 levels and percentage of CD4 subsets between the two groups during the 1st year of HIV infection. We found no differences between the two groups regarding the percentage of naïve, central memory and effector memory subsets of CD4 cells during the 1st year of HIV-1 infection. CCR5 levels on CD4+ CM subset was higher in the CD4 Low group compared with the CD4 High group during the 1st year of HIV-1 infection. High CCR5 levels on CD4 central memory cells in acute HIV infection are mostly associated with rapid disease progression. Our data suggest that low CCR5 expression on CD4 central memory cells protects CD4 cells from direct virus infection and favors the preservation of CD4(+) T cell homeostasis. Public Library of Science 2012-11-21 /pmc/articles/PMC3504013/ /pubmed/23185351 http://dx.doi.org/10.1371/journal.pone.0049526 Text en © 2012 Yang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Yang, Xue
Jiao, Yan-mei
Wang, Rui
Ji, Yun-xia
Zhang, Hong-wei
Zhang, Yong-hong
Chen, De-xi
Zhang, Tong
Wu, Hao
High CCR5 Density on Central Memory CD4(+) T Cells in Acute HIV-1 Infection Is Mostly Associated with Rapid Disease Progression
title High CCR5 Density on Central Memory CD4(+) T Cells in Acute HIV-1 Infection Is Mostly Associated with Rapid Disease Progression
title_full High CCR5 Density on Central Memory CD4(+) T Cells in Acute HIV-1 Infection Is Mostly Associated with Rapid Disease Progression
title_fullStr High CCR5 Density on Central Memory CD4(+) T Cells in Acute HIV-1 Infection Is Mostly Associated with Rapid Disease Progression
title_full_unstemmed High CCR5 Density on Central Memory CD4(+) T Cells in Acute HIV-1 Infection Is Mostly Associated with Rapid Disease Progression
title_short High CCR5 Density on Central Memory CD4(+) T Cells in Acute HIV-1 Infection Is Mostly Associated with Rapid Disease Progression
title_sort high ccr5 density on central memory cd4(+) t cells in acute hiv-1 infection is mostly associated with rapid disease progression
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504013/
https://www.ncbi.nlm.nih.gov/pubmed/23185351
http://dx.doi.org/10.1371/journal.pone.0049526
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