The Auto-Inhibitory Role of the EPAC Hinge Helix as Mapped by NMR

The cyclic-AMP binding domain (CBD) is the central regulatory unit of exchange proteins activated by cAMP (EPAC). The CBD maintains EPAC in a state of auto-inhibition in the absence of the allosteric effector, cAMP. When cAMP binds to the CBD such auto-inhibition is released, leading to EPAC activat...

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Detalles Bibliográficos
Autores principales: Selvaratnam, Rajeevan, Mazhab-Jafari, Mohammad T., Das, Rahul, Melacini, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504058/
https://www.ncbi.nlm.nih.gov/pubmed/23185272
http://dx.doi.org/10.1371/journal.pone.0048707

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504058/
https://www.ncbi.nlm.nih.gov/pubmed/23185272
http://dx.doi.org/10.1371/journal.pone.0048707

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