Gefitinib Analogue V1801 Induces Apoptosis of T790M EGFR-Harboring Lung Cancer Cells by Up-Regulation of the BH-3 Only Protein Noxa

Treatment of non-small cell lung cancer (NSCLC) with drugs targeting the epidermal growth factor receptor (EGFR), e.g., gefitinib and erlotinib, will eventually fail because of the development of secondary mutations such as T790M in EGFR. Strategies to overcome this resistance are therefore an urgen...

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Detalles Bibliográficos
Autores principales: Zhang, Bo, Jiao, Jiao, Liu, Ying, Guo, Liang-Xia, Zhou, Bo, Li, Gang-Qin, Yao, Zhu-Jun, Zhou, Guang-Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504066/
https://www.ncbi.nlm.nih.gov/pubmed/23185274
http://dx.doi.org/10.1371/journal.pone.0048748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504066/
https://www.ncbi.nlm.nih.gov/pubmed/23185274
http://dx.doi.org/10.1371/journal.pone.0048748

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