Mycophenolic Acid Overcomes Imatinib and Nilotinib Resistance of Chronic Myeloid Leukemia Cells by Apoptosis or a Senescent-Like Cell Cycle Arrest

We used K562 cells sensitive or generated resistant to imatinib or nilotinib to investigate their response to mycophenolic acid (MPA). MPA induced DNA damage leading to cell death with a minor contribution of apoptosis, as revealed by annexin V labeling (up to 25%). In contrast, cell cycle arrest an...

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Detalles Bibliográficos
Autores principales: Drullion, Claire, Lagarde, Valérie, Gioia, Romain, Legembre, Patrick, Priault, Muriel, Cardinaud, Bruno, Lippert, Eric, Mahon, François-Xavier, Pasquet, Jean-Max
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504262/
https://www.ncbi.nlm.nih.gov/pubmed/23213550
http://dx.doi.org/10.1155/2012/861301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504262/
https://www.ncbi.nlm.nih.gov/pubmed/23213550
http://dx.doi.org/10.1155/2012/861301

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