Transcriptional Silencing of Transposons by Piwi and Maelstrom and Its Impact on Chromatin State and Gene Expression

Eukaryotic genomes are colonized by transposons whose uncontrolled activity causes genomic instability. The piRNA pathway silences transposons in animal gonads, yet how this is achieved molecularly remains controversial. Here, we show that the HMG protein Maelstrom is essential for Piwi-mediated sil...

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Detalles Bibliográficos
Autores principales: Sienski, Grzegorz, Dönertas, Derya, Brennecke, Julius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504300/
https://www.ncbi.nlm.nih.gov/pubmed/23159368
http://dx.doi.org/10.1016/j.cell.2012.10.040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504300/
https://www.ncbi.nlm.nih.gov/pubmed/23159368
http://dx.doi.org/10.1016/j.cell.2012.10.040

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