TGF-β conditions intestinal T cells to express increased levels of miR-155, associated with down-regulation of IL-2 and itk mRNA

Transforming Growth Factor (TGF)-β, is an immunosuppressive cytokine that inhibits T cell activation. We hypothesized that TGF-β mediates its immuno-inhibitory effects by modulation of micro (mi)RNA-155. IL-2 and IFN-γ are down-regulated by TGF-β in activated CD4 peripheral blood T cells (PBT) and l...

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Detalles Bibliográficos
Autores principales: Das, Lopa M., Torres-Castillo, Maria D.L.A., Gill, Tejpal, Levine, Alan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504619/
https://www.ncbi.nlm.nih.gov/pubmed/22785227
http://dx.doi.org/10.1038/mi.2012.60

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504619/
https://www.ncbi.nlm.nih.gov/pubmed/22785227
http://dx.doi.org/10.1038/mi.2012.60

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