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TGF-β conditions intestinal T cells to express increased levels of miR-155, associated with down-regulation of IL-2 and itk mRNA
Transforming Growth Factor (TGF)-β, is an immunosuppressive cytokine that inhibits T cell activation. We hypothesized that TGF-β mediates its immuno-inhibitory effects by modulation of micro (mi)RNA-155. IL-2 and IFN-γ are down-regulated by TGF-β in activated CD4 peripheral blood T cells (PBT) and l...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504619/ https://www.ncbi.nlm.nih.gov/pubmed/22785227 http://dx.doi.org/10.1038/mi.2012.60 |