Accelerated Disassembly of IgE:Receptor Complexes by a Disruptive Macromolecular Inhibitor

IgE antibodies bind the high affinity IgE Fc receptor (FcεRI), found primarily on mast cells and basophils, and trigger inflammatory cascades of the allergic response(1,2). Inhibitors of IgE:FcεRI binding have been identified and an anti-IgE therapeutic antibody (omalizumab) is used to treat severe...

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Detalles Bibliográficos
Autores principales: Kim, Beomkyu, Eggel, Alexander, Tarchevskaya, Svetlana S., Vogel, Monique, Prinz, Heino, Jardetzky, Theodore S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504642/
https://www.ncbi.nlm.nih.gov/pubmed/23103871
http://dx.doi.org/10.1038/nature11546

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504642/
https://www.ncbi.nlm.nih.gov/pubmed/23103871
http://dx.doi.org/10.1038/nature11546

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