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Accelerated Disassembly of IgE:Receptor Complexes by a Disruptive Macromolecular Inhibitor
IgE antibodies bind the high affinity IgE Fc receptor (FcεRI), found primarily on mast cells and basophils, and trigger inflammatory cascades of the allergic response(1,2). Inhibitors of IgE:FcεRI binding have been identified and an anti-IgE therapeutic antibody (omalizumab) is used to treat severe...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504642/ https://www.ncbi.nlm.nih.gov/pubmed/23103871 http://dx.doi.org/10.1038/nature11546 |