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Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis

The tumor-suppressor p53 can induce various biological responses. Yet, it is not clear whether it is p53 in vivo promoter selectivity that triggers different transcription programs leading to different outcomes. Our analysis of genome-wide chromatin occupancy by p53 using chromatin immunoprecipitati...

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Detalles Bibliográficos
Autores principales: Nikulenkov, F, Spinnler, C, Li, H, Tonelli, C, Shi, Y, Turunen, M, Kivioja, T, Ignatiev, I, Kel, A, Taipale, J, Selivanova, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504713/
https://www.ncbi.nlm.nih.gov/pubmed/22790872
http://dx.doi.org/10.1038/cdd.2012.89