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Smaller sample sizes for phase II trials based on exact tests with actual error rates by trading-off their nominal levels of significance and power
BACKGROUND: Sample sizes for single-stage phase II clinical trials in the literature are often based on exact (binomial) tests with levels of significance (alpha (α) <5% and power >80%). This is because there is not always a sample size where α and power are exactly equal to 5% and 80%, respec...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504941/ https://www.ncbi.nlm.nih.gov/pubmed/23169334 http://dx.doi.org/10.1038/bjc.2012.444 |