Technical and biological variance structure in mRNA-Seq data: life in the real world

BACKGROUND: mRNA expression data from next generation sequencing platforms is obtained in the form of counts per gene or exon. Counts have classically been assumed to follow a Poisson distribution in which the variance is equal to the mean. The Negative Binomial distribution which allows for over-di...

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Detalles Bibliográficos
Autores principales: Oberg, Ann L, Bot, Brian M, Grill, Diane E, Poland, Gregory A, Therneau, Terry M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505161/
https://www.ncbi.nlm.nih.gov/pubmed/22769017
http://dx.doi.org/10.1186/1471-2164-13-304

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505161/
https://www.ncbi.nlm.nih.gov/pubmed/22769017
http://dx.doi.org/10.1186/1471-2164-13-304

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