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Technical and biological variance structure in mRNA-Seq data: life in the real world

BACKGROUND: mRNA expression data from next generation sequencing platforms is obtained in the form of counts per gene or exon. Counts have classically been assumed to follow a Poisson distribution in which the variance is equal to the mean. The Negative Binomial distribution which allows for over-di...

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Detalles Bibliográficos
Autores principales:	Oberg, Ann L, Bot, Brian M, Grill, Diane E, Poland, Gregory A, Therneau, Terry M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505161/ https://www.ncbi.nlm.nih.gov/pubmed/22769017 http://dx.doi.org/10.1186/1471-2164-13-304

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