Cyclization of Fungal Nonribosomal Peptides by a Terminal Condensation-Like Domain

Cyclization of linear peptidyl precursors produced by nonribosomal peptide synthetases (NRPSs) is an important step in the biosynthesis of bioactive cyclic peptides. Whereas bacterial NRPSs use thioesterase (TE) domains to perform the cyclization, fungal NRPSs have apparently evolved to use a differ...

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Detalles Bibliográficos
Autores principales: Gao, Xue, Haynes, Stuart W., Ames, Brian D., Wang, Peng, Vien, Linda P., Walsh, Christopher T., Tang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505271/
https://www.ncbi.nlm.nih.gov/pubmed/22902615
http://dx.doi.org/10.1038/nchembio.1047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505271/
https://www.ncbi.nlm.nih.gov/pubmed/22902615
http://dx.doi.org/10.1038/nchembio.1047

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