Tamoxifen Regulates Cell Fate Through Mitochondrial Estrogen Receptor Beta in Breast Cancer

Tamoxifen has both cytostatic and cytotoxic properties for breast cancer. Tamoxifen engaged mitochondrial estrogen receptor beta (ERβ) as an antagonist in MCF-7 BK cells, increasing reactive oxygen species (ROS) concentrations from the mitochondria that were required for cytotoxicity. In part this d...

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Detalles Bibliográficos
Autores principales: Razandi, Mahnaz, Pedram, Ali, Jordan, V Craig, Fuqua, Suzanne, Levin, Ellis R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505272/
https://www.ncbi.nlm.nih.gov/pubmed/22907432
http://dx.doi.org/10.1038/onc.2012.335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505272/
https://www.ncbi.nlm.nih.gov/pubmed/22907432
http://dx.doi.org/10.1038/onc.2012.335

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