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Selective delivery of interleukine-1 receptor antagonist to inflamed joint by albumin fusion
BACKGROUND: Interleukin-1 receptor antagonist, a cytokine that is highly therapeutic to rheumatoid arthritis and several other inflammatory diseases, exhibits rapid blood clearance and poor retention time on the target in clinical application due to its small size and lack of specificity to target t...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505484/ https://www.ncbi.nlm.nih.gov/pubmed/23006786 http://dx.doi.org/10.1186/1472-6750-12-68 |