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Generation of animals allowing the conditional inactivation of the Pax4 gene

Pax4 belongs to the paired-box family of transcription factors. The analysis of loss- and gain-of-function mutant animals revealed that this factor plays a crucial role in the endocrine pancreas. Indeed, Pax4 is required for the genesis of insulin-producing beta-cells. Remarkably, the sole misexpres...

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Detalles Bibliográficos
Autores principales: Kordowich, Simon, Serup, Palle, Collombat, Patrick, Mansouri, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505494/
https://www.ncbi.nlm.nih.gov/pubmed/22717987
http://dx.doi.org/10.1007/s11248-012-9624-0