Knockdown of IKK1/2 Promotes Differentiation of Mouse Embryonic Stem Cells into Neuroectoderm at the Expense of Mesoderm

Activation of nuclear factor kappa B (NF-κB) is accomplished by a specific kinase complex (IKK-complex), phosphorylating inhibitors of NF-κB (IκB). In embryonic stem cells (ESCs), NF-κB signaling causes loss of pluripotency and promotes differentiation towards a mesodermal phenotype. Here we show th...

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Detalles Bibliográficos
Autores principales: Lüningschrör, Patrick, Kaltschmidt, Barbara, Kaltschmidt, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Humana Press Inc 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505544/
https://www.ncbi.nlm.nih.gov/pubmed/22833419
http://dx.doi.org/10.1007/s12015-012-9402-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505544/
https://www.ncbi.nlm.nih.gov/pubmed/22833419
http://dx.doi.org/10.1007/s12015-012-9402-7

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