Three-Dimensional Pharmacophore Design and Biochemical Screening Identifies Substituted 1,2,4-Triazoles as Inhibitors of the Annexin A2–S100A10 Protein Interaction

ABSTRACT: Protein interactions are increasingly appreciated as targets in small-molecule drug discovery. The interaction between the adapter protein S100A10 and its binding partner annexin A2 is a potentially important drug target. To obtain small-molecule starting points for inhibitors of this inte...

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Detalles Bibliográficos
Autores principales: Reddy, Tummala R K, Li, Chan, Fischer, Peter M, Dekker, Lodewijk V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2012
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505905/
https://www.ncbi.nlm.nih.gov/pubmed/22644793
http://dx.doi.org/10.1002/cmdc.201200107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505905/
https://www.ncbi.nlm.nih.gov/pubmed/22644793
http://dx.doi.org/10.1002/cmdc.201200107

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