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Three-Dimensional Pharmacophore Design and Biochemical Screening Identifies Substituted 1,2,4-Triazoles as Inhibitors of the Annexin A2–S100A10 Protein Interaction

ABSTRACT: Protein interactions are increasingly appreciated as targets in small-molecule drug discovery. The interaction between the adapter protein S100A10 and its binding partner annexin A2 is a potentially important drug target. To obtain small-molecule starting points for inhibitors of this inte...

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Detalles Bibliográficos
Autores principales:	Reddy, Tummala R K, Li, Chan, Fischer, Peter M, Dekker, Lodewijk V
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	WILEY-VCH Verlag 2012
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505905/ https://www.ncbi.nlm.nih.gov/pubmed/22644793 http://dx.doi.org/10.1002/cmdc.201200107

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