[(11)C]phenytoin revisited: synthesis by [(11)C]CO carbonylation and first evaluation as a P-gp tracer in rats

BACKGROUND: At present, several positron emission tomography (PET) tracers are in use for imaging P-glycoprotein (P-gp) function in man. At baseline, substrate tracers such as R-[(11)C]verapamil display low brain concentrations with a distribution volume of around 1. [(11)C]phenytoin is supposed to...

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Detalles Bibliográficos
Autores principales: Verbeek, Joost, Eriksson, Jonas, Syvänen, Stina, Labots, Maaike, de Lange, Elizabeth C M, Voskuyl, Rob A, Mooijer, Martinus P J, Rongen, Marissa, Lammertsma, Adriaan A, Windhorst, Albert D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506555/
https://www.ncbi.nlm.nih.gov/pubmed/22747744
http://dx.doi.org/10.1186/2191-219X-2-36

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506555/
https://www.ncbi.nlm.nih.gov/pubmed/22747744
http://dx.doi.org/10.1186/2191-219X-2-36

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