Prediction of Protein-Destabilizing Polymorphisms by Manual Curation with Protein Structure

The relationship between sequence polymorphisms and human disease has been studied mostly in terms of effects of single nucleotide polymorphisms (SNPs) leading to single amino acid substitutions that change protein structure and function. However, less attention has been paid to more drastic sequenc...

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Detalles Bibliográficos
Autores principales: Gough, Craig Alan, Homma, Keiichi, Yamaguchi-Kabata, Yumi, Shimada, Makoto K., Chakraborty, Ranajit, Fujii, Yasuyuki, Iwama, Hisakazu, Minoshima, Shinsei, Sakamoto, Shigetaka, Sato, Yoshiharu, Suzuki, Yoshiyuki, Tada-Umezaki, Masahito, Nishikawa, Ken, Imanishi, Tadashi, Gojobori, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506574/
https://www.ncbi.nlm.nih.gov/pubmed/23189203
http://dx.doi.org/10.1371/journal.pone.0050445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506574/
https://www.ncbi.nlm.nih.gov/pubmed/23189203
http://dx.doi.org/10.1371/journal.pone.0050445

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