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Learning from Decoys to Improve the Sensitivity and Specificity of Proteomics Database Search Results
The statistical validation of database search results is a complex issue in bottom-up proteomics. The correct and incorrect peptide spectrum match (PSM) scores overlap significantly, making an accurate assessment of true peptide matches challenging. Since the complete separation between the true and...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506577/ https://www.ncbi.nlm.nih.gov/pubmed/23189209 http://dx.doi.org/10.1371/journal.pone.0050651 |