Blockade of the BAK Hydrophobic Groove by Inhibitory Phosphorylation Regulates Commitment to Apoptosis

The BCL-2 family protein BAK is a key regulator of mitochondrial apoptosis. BAK activation first involves N-terminal conformational changes that lead to the transient exposure of the BAK BH3 domain that then inserts into a hydrophobic groove on another BAK molecule to form symmetric dimers. We showe...

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Detalles Bibliográficos
Autores principales: Azad, Abul, Fox, Joanna, Leverrier, Sabrina, Storey, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506661/
https://www.ncbi.nlm.nih.gov/pubmed/23189150
http://dx.doi.org/10.1371/journal.pone.0049601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506661/
https://www.ncbi.nlm.nih.gov/pubmed/23189150
http://dx.doi.org/10.1371/journal.pone.0049601

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