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Centrosome loss or amplification does not dramatically perturb global gene expression in Drosophila

Centrosome defects are a common feature of many cancers, and they can predispose fly brain cells to form tumours. In flies, centrosome defects perturb the asymmetric division of the neural stem cells, but it is unclear how this might lead to malignant transformation. One possibility is that centroso...

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Detalles Bibliográficos
Autores principales: Baumbach, Janina, Levesque, Mitchell P., Raff, Jordan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507170/
https://www.ncbi.nlm.nih.gov/pubmed/23213376
http://dx.doi.org/10.1242/bio.20122238