Defects in GPI biosynthesis perturb Cripto signaling during forebrain development in two new mouse models of holoprosencephaly

Holoprosencephaly is the most common forebrain defect in humans. We describe two novel mouse mutants that display a holoprosencephaly-like phenotype. Both mutations disrupt genes in the glycerophosphatidyl inositol (GPI) biosynthesis pathway: gonzo disrupts Pign and beaker disrupts Pgap1. GPI anchor...

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Detalles Bibliográficos
Autores principales: McKean, David M., Niswander, Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507239/
https://www.ncbi.nlm.nih.gov/pubmed/23213481
http://dx.doi.org/10.1242/bio.20121982

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507239/
https://www.ncbi.nlm.nih.gov/pubmed/23213481
http://dx.doi.org/10.1242/bio.20121982

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