hMTH1 expression protects mitochondria from Huntington's disease-like impairment

Huntington disease (HD) is a neurodegenerative disease caused by expansion of CAG repeats in the huntingtin (Htt) gene. The expression of hMTH1, the human hydrolase that degrades oxidized purine nucleoside triphosphates, grants protection in a chemical HD mouse model in which HD-like features are in...

Descripción completa

Detalles Bibliográficos
Autores principales: Ventura, Ilenia, Russo, Maria Teresa, De Nuccio, Chiara, De Luca, Gabriele, Degan, Paolo, Bernardo, Antonietta, Visentin, Sergio, Minghetti, Luisa, Bignami, Margherita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507627/
https://www.ncbi.nlm.nih.gov/pubmed/22974734
http://dx.doi.org/10.1016/j.nbd.2012.09.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507627/
https://www.ncbi.nlm.nih.gov/pubmed/22974734
http://dx.doi.org/10.1016/j.nbd.2012.09.002

Ejemplares similares