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Clinical course of preterm prelabor rupture of membranes in the era of prophylactic antibiotics
BACKGROUND: Preterm prelabor rupture of membrane (PPROM) causes maternal and neonatal complications. Prophylactic antiobiotics were used in the management of PPROM. The objectives of this retrospective study were to compare clinical course and outcome of PPROM managed expectantly with prophylactic a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507817/ https://www.ncbi.nlm.nih.gov/pubmed/22999078 http://dx.doi.org/10.1186/1756-0500-5-515 |
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author | Phupong, Vorapong Kulmala, Lalita |
author_facet | Phupong, Vorapong Kulmala, Lalita |
author_sort | Phupong, Vorapong |
collection | PubMed |
description | BACKGROUND: Preterm prelabor rupture of membrane (PPROM) causes maternal and neonatal complications. Prophylactic antiobiotics were used in the management of PPROM. The objectives of this retrospective study were to compare clinical course and outcome of PPROM managed expectantly with prophylactic antibiotics and antenatal corticosteroids with those without prophylactic antibiotics and antenatal corticosteroids. RESULTS: A total of 170 cases of singleton pregnant women with gestational age between 28–34 weeks suffering from PROM during January 1998 to December 2009 were included; 119 cases received prophylactic antibiotics and antenatal corticosteroids while 51 cases did not received prophylactic antibiotics and antenatal corticosteroids. Median latency period in the study group was significantly longer than in the control group (89.8 vs. 24.3 hours, P < 0.001). The percentage of patients who did not deliver within 48 hours and within 7 days in the study group were also significantly higher than in control group (64.7 vs. 31.4%, P < 0.001 and 29.4 vs. 7.8%, P = 0.002, respectively). Maternal infectious morbidity was comparable between groups (17.6% vs. 13.7%, P = 0.52). Neonatal infectious morbidity was significantly lesser in study group than control group (21% vs. 35.3%, p = 0.04). CONCLUSIONS: Latency period of PPROM after using prophylactic antibiotics and antenatal corticosteroids increased while neonatal infectious morbidity was low. But maternal infectious morbidity was not increased. This retrospective study confirms the benefit of prophylactic antibiotics and antenatal corticosteroids in management of PPROM. |
format | Online Article Text |
id | pubmed-3507817 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-35078172012-11-28 Clinical course of preterm prelabor rupture of membranes in the era of prophylactic antibiotics Phupong, Vorapong Kulmala, Lalita BMC Res Notes Research Article BACKGROUND: Preterm prelabor rupture of membrane (PPROM) causes maternal and neonatal complications. Prophylactic antiobiotics were used in the management of PPROM. The objectives of this retrospective study were to compare clinical course and outcome of PPROM managed expectantly with prophylactic antibiotics and antenatal corticosteroids with those without prophylactic antibiotics and antenatal corticosteroids. RESULTS: A total of 170 cases of singleton pregnant women with gestational age between 28–34 weeks suffering from PROM during January 1998 to December 2009 were included; 119 cases received prophylactic antibiotics and antenatal corticosteroids while 51 cases did not received prophylactic antibiotics and antenatal corticosteroids. Median latency period in the study group was significantly longer than in the control group (89.8 vs. 24.3 hours, P < 0.001). The percentage of patients who did not deliver within 48 hours and within 7 days in the study group were also significantly higher than in control group (64.7 vs. 31.4%, P < 0.001 and 29.4 vs. 7.8%, P = 0.002, respectively). Maternal infectious morbidity was comparable between groups (17.6% vs. 13.7%, P = 0.52). Neonatal infectious morbidity was significantly lesser in study group than control group (21% vs. 35.3%, p = 0.04). CONCLUSIONS: Latency period of PPROM after using prophylactic antibiotics and antenatal corticosteroids increased while neonatal infectious morbidity was low. But maternal infectious morbidity was not increased. This retrospective study confirms the benefit of prophylactic antibiotics and antenatal corticosteroids in management of PPROM. BioMed Central 2012-09-22 /pmc/articles/PMC3507817/ /pubmed/22999078 http://dx.doi.org/10.1186/1756-0500-5-515 Text en Copyright ©2012 Phupong and Kulmala; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Phupong, Vorapong Kulmala, Lalita Clinical course of preterm prelabor rupture of membranes in the era of prophylactic antibiotics |
title | Clinical course of preterm prelabor rupture of membranes in the era of prophylactic antibiotics |
title_full | Clinical course of preterm prelabor rupture of membranes in the era of prophylactic antibiotics |
title_fullStr | Clinical course of preterm prelabor rupture of membranes in the era of prophylactic antibiotics |
title_full_unstemmed | Clinical course of preterm prelabor rupture of membranes in the era of prophylactic antibiotics |
title_short | Clinical course of preterm prelabor rupture of membranes in the era of prophylactic antibiotics |
title_sort | clinical course of preterm prelabor rupture of membranes in the era of prophylactic antibiotics |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507817/ https://www.ncbi.nlm.nih.gov/pubmed/22999078 http://dx.doi.org/10.1186/1756-0500-5-515 |
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