Characterization of Oligomers of Heterogeneous Size as Precursors of Amyloid Fibril Nucleation of an SH3 Domain: An Experimental Kinetics Study

Understanding the earliest molecular events during nucleation of the amyloid aggregation cascade is of fundamental significance to prevent amyloid related disorders. We report here an experimental kinetic analysis of the amyloid aggregation of the N47A mutant of the α-spectrin SH3 domain (N47A Spc-S...

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Detalles Bibliográficos
Autores principales: Ruzafa, David, Morel, Bertrand, Varela, Lorena, Azuaga, Ana I., Conejero-Lara, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507826/
https://www.ncbi.nlm.nih.gov/pubmed/23209591
http://dx.doi.org/10.1371/journal.pone.0049690

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507826/
https://www.ncbi.nlm.nih.gov/pubmed/23209591
http://dx.doi.org/10.1371/journal.pone.0049690

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