Cellular Inclusion Bodies of Mutant Huntingtin Exon 1 Obscure Small Fibrillar Aggregate Species

The identities of toxic aggregate species in Huntington's disease pathogenesis remain ambiguous. While polyQ-expanded huntingtin (Htt) is known to accumulate in compact inclusion bodies inside neurons, this is widely thought to be a protective coping response that sequesters misfolded conformat...

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Detalles Bibliográficos
Autores principales: Sahl, Steffen J., Weiss, Lucien E., Duim, Whitney C., Frydman, Judith, Moerner, W. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508451/
https://www.ncbi.nlm.nih.gov/pubmed/23193437
http://dx.doi.org/10.1038/srep00895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508451/
https://www.ncbi.nlm.nih.gov/pubmed/23193437
http://dx.doi.org/10.1038/srep00895

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