Peptide binding to HLA-DP proteins at pH 5.0 and pH 7.0: a quantitative molecular docking study

BACKGROUND: HLA-DPs are class II MHC proteins mediating immune responses to many diseases. Peptides bind MHC class II proteins in the acidic environment within endosomes. Acidic pH markedly elevates association rate constants but dissociation rates are almost unchanged in the pH range 5.0 – 7.0. Thi...

Descripción completa

Detalles Bibliográficos
Autores principales: Patronov, Atanas, Dimitrov, Ivan, Flower, Darren R, Doytchinova, Irini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508589/
https://www.ncbi.nlm.nih.gov/pubmed/22862845
http://dx.doi.org/10.1186/1472-6807-12-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508589/
https://www.ncbi.nlm.nih.gov/pubmed/22862845
http://dx.doi.org/10.1186/1472-6807-12-20

Ejemplares similares