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Peptide binding to HLA-DP proteins at pH 5.0 and pH 7.0: a quantitative molecular docking study
BACKGROUND: HLA-DPs are class II MHC proteins mediating immune responses to many diseases. Peptides bind MHC class II proteins in the acidic environment within endosomes. Acidic pH markedly elevates association rate constants but dissociation rates are almost unchanged in the pH range 5.0 – 7.0. Thi...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508589/ https://www.ncbi.nlm.nih.gov/pubmed/22862845 http://dx.doi.org/10.1186/1472-6807-12-20 |