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Novel Conformation of an RNA Structural Switch

[Image: see text] The RNA duplex, (5′GACGAGUGUCA)(2), has two conformations in equilibrium. The nuclear magnetic resonance solution structure reveals that the major conformation of the loop, 5′GAGU/3′UGAG, is novel and contains two unusual Watson–Crick/Hoogsteen GG pairs with G residues in the syn c...

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Detalles Bibliográficos
Autores principales: Kennedy, Scott D., Kierzek, Ryszard, Turner, Douglas H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508625/
https://www.ncbi.nlm.nih.gov/pubmed/23134175
http://dx.doi.org/10.1021/bi301372t