Progranulin regulates neuronal outgrowth independent of Sortilin

BACKGROUND: Progranulin (PGRN), a widely secreted growth factor, is involved in multiple biological functions, and mutations located within the PGRN gene (GRN) are a major cause of frontotemporal lobar degeneration with TDP-43-positive inclusions (FLTD-TDP). In light of recent reports suggesting PGR...

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Detalles Bibliográficos
Autores principales: Gass, Jennifer, Lee, Wing C, Cook, Casey, Finch, Nicole, Stetler, Caroline, Jansen-West, Karen, Lewis, Jada, Link, Christopher D, Rademakers, Rosa, Nykjær, Anders, Petrucelli, Leonard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508877/
https://www.ncbi.nlm.nih.gov/pubmed/22781549
http://dx.doi.org/10.1186/1750-1326-7-33

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508877/
https://www.ncbi.nlm.nih.gov/pubmed/22781549
http://dx.doi.org/10.1186/1750-1326-7-33

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