Use of Mutated Self-Cleaving 2A Peptides as a Molecular Rheostat to Direct Simultaneous Formation of Membrane and Secreted Anti-HIV Immunoglobulins

In nature, B cells produce surface immunoglobulin and secreted antibody from the same immunoglobulin gene via alternative splicing of the pre-messenger RNA. Here we present a novel system for genetically programming B cells to direct the simultaneous formation of membrane-bound and secreted immunogl...

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Detalles Bibliográficos
Autores principales: Yu, Kenneth K., Aguilar, Kiefer, Tsai, Jonathan, Galimidi, Rachel, Gnanapragasam, Priyanthi, Yang, Lili, Baltimore, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508920/
https://www.ncbi.nlm.nih.gov/pubmed/23209743
http://dx.doi.org/10.1371/journal.pone.0050438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508920/
https://www.ncbi.nlm.nih.gov/pubmed/23209743
http://dx.doi.org/10.1371/journal.pone.0050438

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