A Functional Variant in the MTOR Promoter Modulates Its Expression and Is Associated with Renal Cell Cancer Risk

BACKGROUND: The mTOR signaling pathway plays a crucial role in the carcinogenesis of renal cell cancer (RCC). We sought to investigate the influence of genetic variations in the mTOR pathway-related genes on the risk of RCC. METHODS: We genotyped 8 potentially functional polymorphisms in AKT1, AKT2,...

Descripción completa

Detalles Bibliográficos
Autores principales: Cao, Qiang, Ju, Xiaobing, Li, Pu, Meng, Xiaoxin, Shao, Pengfei, Cai, Hongzhou, Wang, Meilin, Zhang, Zhengdong, Qin, Chao, Yin, Changjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508984/
https://www.ncbi.nlm.nih.gov/pubmed/23209702
http://dx.doi.org/10.1371/journal.pone.0050302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508984/
https://www.ncbi.nlm.nih.gov/pubmed/23209702
http://dx.doi.org/10.1371/journal.pone.0050302

Ejemplares similares