Cargando…

A Functional Variant in the MTOR Promoter Modulates Its Expression and Is Associated with Renal Cell Cancer Risk

BACKGROUND: The mTOR signaling pathway plays a crucial role in the carcinogenesis of renal cell cancer (RCC). We sought to investigate the influence of genetic variations in the mTOR pathway-related genes on the risk of RCC. METHODS: We genotyped 8 potentially functional polymorphisms in AKT1, AKT2,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cao, Qiang, Ju, Xiaobing, Li, Pu, Meng, Xiaoxin, Shao, Pengfei, Cai, Hongzhou, Wang, Meilin, Zhang, Zhengdong, Qin, Chao, Yin, Changjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508984/ https://www.ncbi.nlm.nih.gov/pubmed/23209702 http://dx.doi.org/10.1371/journal.pone.0050302

Ejemplares similares

One-Carbon Metabolism Pathway Gene Variants and Risk of Clear Cell Renal Cell Carcinoma in a Chinese Population
por: Zhang, Lei, et al.
Publicado: (2013)

Functional promoter -31G/C variant of Survivin gene predict prostate cancer susceptibility among Chinese: a case control study
por: Chen, Jiawei, et al.
Publicado: (2013)

Genetic Variations in a PTEN/AKT/mTOR Axis and Prostate Cancer Risk in a Chinese Population
por: Chen, Jiawei, et al.
Publicado: (2012)

Functional Promoter -31G>C Variant in Survivin Gene Is Associated with Risk and Progression of Renal Cell Cancer in a Chinese Population
por: Qin, Chao, et al.
Publicado: (2012)

Genetic Polymorphisms in IGF-I and IGFBP-3 Are Associated with Prostate Cancer in the Chinese Population
por: Qian, Jian, et al.
Publicado: (2014)

Genetic Variants in RKIP Are Associated with Clear Cell Renal Cell Carcinoma Risk in a Chinese Population
por: Cao, Qiang, et al.
Publicado: (2014)

Genetic Variant in Long Non-Coding RNA H19 Modulates Its Expression and Predicts Renal Cell Carcinoma Susceptibility and Mortality
por: Cao, Qiang, et al.
Publicado: (2020)

Retroperitoneal laparoscopic technique in treatment of complex renal stones: 75 cases
por: Qin, Chao, et al.
Publicado: (2014)

The influence of genetic variants of sorafenib on clinical outcomes and toxic effects in patients with advanced renal cell carcinoma
por: Qin, Chao, et al.
Publicado: (2016)

Expression Pattern of Long Non-Coding RNAs in Renal Cell Carcinoma Revealed by Microarray
por: Qin, Chao, et al.
Publicado: (2014)

Modified liver mobilization for the treatment of renal cell carcinoma with thrombosis involving the intrahepatic inferior vena cava
por: Han, Zhijian, et al.
Publicado: (2014)

A Genetic Variant in pre-miR-27a Is Associated with a Reduced Renal Cell Cancer Risk in a Chinese Population
por: Shi, Danni, et al.
Publicado: (2012)

Genetic variation in IGF1 predicts renal cell carcinoma susceptibility and prognosis in Chinese population
por: Cao, Qiang, et al.
Publicado: (2016)

TSP-1-1223 A/G Polymorphism as a Potential Predictor of the Recurrence Risk of Bladder Cancer in a Chinese Population
por: Yang, Xiao, et al.
Publicado: (2013)

Association of erythropoietin gene rs576236 polymorphism and risk of adrenal tumors in a Chinese population
por: Zhang, Chao, et al.
Publicado: (2014)

Application and analysis of retroperitoneal laparoscopic partial nephrectomy with sequential segmental renal artery clamping for patients with multiple renal tumor: initial experience
por: Zhu, Jundong, et al.
Publicado: (2017)

Meta-Analysis Reveals a Lack of Association between UGT2B17 Deletion Polymorphism and Tumor Susceptibility
por: Deng, Xiaheng, et al.
Publicado: (2014)

CASP8 promoter polymorphism, mRNA expression and risk of prostate cancer among Chinese men()
por: Fu, Guangbo, et al.
Publicado: (2011)

Circulating miR-497 and miR-663b in plasma are potential novel biomarkers for bladder cancer
por: Du, Mulong, et al.
Publicado: (2015)

AB169. Clinical aspects and molecular genetics of persistent müllerian duct syndrome associated with transverse testicular ectopia: report of three cases
por: Ju, Xiaobing, et al.
Publicado: (2014)

Identification of circulating microRNA signatures for upper tract urothelial carcinoma detection
por: TAO, JUN, et al.
Publicado: (2015)

Genetic Variation in DROSHA 3’UTR Regulated by hsa-miR-27b Is Associated with Bladder Cancer Risk
por: Yuan, Lin, et al.
Publicado: (2013)

A novel antisense long noncoding RNA regulates the expression of MDC1 in bladder cancer
por: Xue, Yao, et al.
Publicado: (2014)

Association Between MIF-AS rs755622 and Nephrolithiasis Risk in a Chinese Population
por: Ma, Gaoxiang, et al.
Publicado: (2016)

LncRNA BCLET variant confers bladder cancer susceptibility through alternative splicing of MSANTD2 exon 1
por: Liu, Hanting, et al.
Publicado: (2023)

Silencing CAPN2 Expression Inhibited Castration-Resistant Prostate Cancer Cells Proliferation and Invasion via AKT/mTOR Signal Pathway
por: Li, Pu, et al.
Publicado: (2017)

Rare variants in BRCA2 and CHEK2 are associated with the risk of urinary tract cancers
por: Ge, Yuqiu, et al.
Publicado: (2016)

The association analysis of hOGG1 genetic variants and gastric cancer risk in a Chinese population
por: Lu, Jiafei, et al.
Publicado: (2016)

LncRNA BCCE4 Genetically Enhances the PD‐L1/PD‐1 Interaction in Smoking‐Related Bladder Cancer by Modulating miR‐328‐3p‐USP18 Signaling
por: Zheng, Rui, et al.
Publicado: (2023)

A Polymorphism (rs2295080) in mTOR Promoter Region and Its Association with Gastric Cancer in a Chinese Population
por: Xu, Ming, et al.
Publicado: (2013)

Evaluation of GWAS-Identified Genetic Variants for Gastric Cancer Survival
por: Gu, Dongying, et al.
Publicado: (2018)

Overexpression of CAPN2 promotes cell metastasis and proliferation via AKT/mTOR signaling in renal cell carcinoma
por: Miao, Chenkui, et al.
Publicado: (2017)

Developing a Follow-Up Strategy for Patients with PSA Ranging from 4 to 10 ng/ml via a New Model to Reduce Unnecessary Prostate Biopsies
por: Zhao, Ruizhe, et al.
Publicado: (2014)

A prostate biopsy strategy based on a new clinical nomogram reduces the number of biopsy cores required in high-risk patients
por: Huang, Yuan, et al.
Publicado: (2014)

The G Allele of CaSR R990G Polymorphism Increases Susceptibility to Urolithiasis and Hypercalciuria: Evidences from a Comprehensive Meta-Analysis
por: Liu, Kang, et al.
Publicado: (2015)

Modulation of mTOR and epigenetic pathways as therapeutics in gallbladder cancer
por: Yang, Dong, et al.
Publicado: (2020)

LncRNA PCAT1 and its genetic variant rs1902432 are associated with prostate cancer risk
por: Yuan, Qinbo, et al.
Publicado: (2018)

CD151 promotes cell metastasis via activating TGF-β1/Smad signaling in renal cell carcinoma
por: Yu, Yajie, et al.
Publicado: (2018)

Functional Promoter -94 ins/del ATTG Polymorphism in NFKB1 Gene Is Associated with Bladder Cancer Risk in a Chinese Population
por: Li, Pengchao, et al.
Publicado: (2013)

Genetics of renal cancer: focus on MTOR
por: Ghosh, Arindam P., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_mk55b6o6qcq6gnusl7p1fuuu0l