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O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis
Protein O-GlcNAcylation is an essential post-translational modification on hundreds of intracellular proteins in metazoa, catalyzed by O-GlcNAc transferase using unknown mechanisms of transfer and substrate recognition. Through crystallographic snapshots and mechanism-inspired chemical probes, we de...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509171/ https://www.ncbi.nlm.nih.gov/pubmed/23103942 http://dx.doi.org/10.1038/nchembio.1108 |