Immunotherapies: The Blockade of Inhibitory Signals

T lymphocytes require signaling by the T cell receptor and by nonclonotypic cosignaling receptors. The costimulatory and inhibitory signals profoundly influence the course of immune responses by amplifying or reducing the transcriptional effects of T cell receptor triggering. The inhibitory receptor...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Yan-Ling, Liang, Jing, Zhang, Wen, Tanaka, Yoshimasa, Sugiyama, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509335/
https://www.ncbi.nlm.nih.gov/pubmed/23197939
http://dx.doi.org/10.7150/ijbs.5273
_version_ 1782251315866370048
author Wu, Yan-Ling
Liang, Jing
Zhang, Wen
Tanaka, Yoshimasa
Sugiyama, Hiroshi
author_facet Wu, Yan-Ling
Liang, Jing
Zhang, Wen
Tanaka, Yoshimasa
Sugiyama, Hiroshi
author_sort Wu, Yan-Ling
collection PubMed
description T lymphocytes require signaling by the T cell receptor and by nonclonotypic cosignaling receptors. The costimulatory and inhibitory signals profoundly influence the course of immune responses by amplifying or reducing the transcriptional effects of T cell receptor triggering. The inhibitory receptors such as CTLA-4, PD-1, and BTLA have recently drawn much attention as potential targets for immunotherapies. This review focuses on the progress that has been made with the mentioned receptors in the field of immunotherapies for autoimmune diseases, malignancies, infectious diseases, and transplantation.
format Online
Article
Text
id pubmed-3509335
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Ivyspring International Publisher
record_format MEDLINE/PubMed
spelling pubmed-35093352012-11-29 Immunotherapies: The Blockade of Inhibitory Signals Wu, Yan-Ling Liang, Jing Zhang, Wen Tanaka, Yoshimasa Sugiyama, Hiroshi Int J Biol Sci Review T lymphocytes require signaling by the T cell receptor and by nonclonotypic cosignaling receptors. The costimulatory and inhibitory signals profoundly influence the course of immune responses by amplifying or reducing the transcriptional effects of T cell receptor triggering. The inhibitory receptors such as CTLA-4, PD-1, and BTLA have recently drawn much attention as potential targets for immunotherapies. This review focuses on the progress that has been made with the mentioned receptors in the field of immunotherapies for autoimmune diseases, malignancies, infectious diseases, and transplantation. Ivyspring International Publisher 2012-11-17 /pmc/articles/PMC3509335/ /pubmed/23197939 http://dx.doi.org/10.7150/ijbs.5273 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Review
Wu, Yan-Ling
Liang, Jing
Zhang, Wen
Tanaka, Yoshimasa
Sugiyama, Hiroshi
Immunotherapies: The Blockade of Inhibitory Signals
title Immunotherapies: The Blockade of Inhibitory Signals
title_full Immunotherapies: The Blockade of Inhibitory Signals
title_fullStr Immunotherapies: The Blockade of Inhibitory Signals
title_full_unstemmed Immunotherapies: The Blockade of Inhibitory Signals
title_short Immunotherapies: The Blockade of Inhibitory Signals
title_sort immunotherapies: the blockade of inhibitory signals
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509335/
https://www.ncbi.nlm.nih.gov/pubmed/23197939
http://dx.doi.org/10.7150/ijbs.5273
work_keys_str_mv AT wuyanling immunotherapiestheblockadeofinhibitorysignals
AT liangjing immunotherapiestheblockadeofinhibitorysignals
AT zhangwen immunotherapiestheblockadeofinhibitorysignals
AT tanakayoshimasa immunotherapiestheblockadeofinhibitorysignals
AT sugiyamahiroshi immunotherapiestheblockadeofinhibitorysignals

Ejemplares similares