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Rab27a Targeting to Melanosomes Requires Nucleotide Exchange but Not Effector Binding

Rab GTPases are important determinants of organelle identity and regulators of vesicular transport pathways. Consequently, each Rab occupies a highly specific subcellular localization. However, the precise mechanisms governing Rab targeting remain unclear. Guanine nucleotide exchange factors (GEFs),...

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Detalles Bibliográficos
Autores principales: Tarafder, Abul K, Wasmeier, Christina, Figueiredo, Ana C, Booth, Antonia E G, Orihara, Asumi, Ramalho, Jose S, Hume, Alistair N, Seabra, Miguel C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509405/
https://www.ncbi.nlm.nih.gov/pubmed/21554507
http://dx.doi.org/10.1111/j.1600-0854.2011.01216.x