Interaction of Lipocalin 2, Transferrin, and Siderophores Determines the Replicative Niche of Klebsiella pneumoniae during Pneumonia

Pathogenic bacteria require iron for replication within their host. Klebsiella pneumoniae and other Gram-negative pathogens produce the prototypical siderophore enterobactin (Ent) to scavenge iron in vivo. In response, mucosal surfaces secrete lipocalin 2 (Lcn2), an innate immune protein that binds...

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Detalles Bibliográficos
Autores principales: Bachman, Michael A., Lenio, Steven, Schmidt, Lindsay, Oyler, Jennifer E., Weiser, Jeffrey N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509427/
https://www.ncbi.nlm.nih.gov/pubmed/23169997
http://dx.doi.org/10.1128/mBio.00224-11

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509427/
https://www.ncbi.nlm.nih.gov/pubmed/23169997
http://dx.doi.org/10.1128/mBio.00224-11

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