Evidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo

The abundant proteoglycan, aggrecan, is resorbed from growth plate cartilage during endochondral bone ossification, yet mice with genetically-ablated aggrecan-degrading activity have no defects in bone formation. To account for this apparent anomaly, we propose that lysosomal hydrolases degrade extr...

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Detalles Bibliográficos
Autores principales: Bastow, Edward R., Last, Karena, Golub, Sue, Stow, Jennifer L., Stanley, Amanda C., Fosang, Amanda J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509456/
https://www.ncbi.nlm.nih.gov/pubmed/23213422
http://dx.doi.org/10.1242/bio.2012547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509456/
https://www.ncbi.nlm.nih.gov/pubmed/23213422
http://dx.doi.org/10.1242/bio.2012547

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