Targeting Death Receptor TRAIL-R2 by Chalcones for TRAIL-Induced Apoptosis in Cancer Cells

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in cancer cells without toxicity to normal cells. TRAIL binds to death receptors, TRAIL-R1 (DR4) and TRAIL-R2 (DR5) expressed on cancer cell surface and activates apoptotic pathways. Endogenous TRAIL plays an important...

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Detalles Bibliográficos
Autores principales: Szliszka, Ewelina, Jaworska, Dagmara, Kłósek, Małgorzata, Czuba, Zenon P., Król, Wojciech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509645/
https://www.ncbi.nlm.nih.gov/pubmed/23203129
http://dx.doi.org/10.3390/ijms131115343

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509645/
https://www.ncbi.nlm.nih.gov/pubmed/23203129
http://dx.doi.org/10.3390/ijms131115343

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